| Pair Name | Curcumin, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PubChem CID: 4713 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | PTEN | hsa5728 | |
| In Vitro Model | MGC-803 | Gastric mucinous adenocarcinoma | Homo sapiens (Human) | CVCL_5334 |
| Result | Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells. J Int Med Res. 2019 Mar;47(3):1288-1297. doi: 10.1177/0300060518822213. | Click |
