| Pair Name | Cucurbitacin I, Fluorouracil | ||
| Phytochemical Name | Cucurbitacin I (PubChem CID: 5281321 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Cucurbitacin I, Fluorouracil | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Expression | MMP9 | hsa4318 |
| Down-regulation | Phosphorylation | STAT3 | hsa6774 | |
| In Vitro Model | COLO 205 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0218 |
| Result | Our results suggest that cucurbitacin I may be a potent adjuvant chemotherapeutic agent for colon cancer with anti-migration, anti-invasion and chemosensitizing activities. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33(4):1867-71. doi: 10.3892/or.2015.3749. | Click |
