InterPAD - DETAILS

Clofarabine, 123318-82-1, Clolar, Evoltra, Clofarex, CAFdA, Cl-F-Ara-A, C1-F-Ara-A, clofarabina, clofarabinum, (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine, CHEBI:681569, 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine, UNII-762RDY0Y2H, Cl-F-araA, 762RDY0Y2H, (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol, DTXSID5046437, NSC-759857, (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, DTXCID3026437, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine, MFCD00871077, NSC 759857, Clofarabine [USAN], CLOFARABINE (MART.), CLOFARABINE [MART.], C10H11ClFN5O3, 2-Chloro-9-(2-Deoxy-2-Fluoro-B -D-Arabinofuranosyl)-9h-Purin-6-Amine, (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol, Clolar (TN), CAS-123318-82-1, 2-Cl-2'-F-araA, Clofarabin, Clofarabine [USAN:INN:BAN], NSC606869, NCGC00164553-01, Clofarabine; Clofarex; Clolar; Evoltra; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine, CLOFARABINE [MI], CLOFARABINE [INN], CLOFARABINE [JAN], 2 Chloro 2' fluoroarabino 2' deoxyadenosine, 2-chloro-2'-fluoroarabino-2'-deoxyadenosine, 2 Chloro 2' arabino fluoro 2' deoxyadenosine, CLOFARABINE [VANDF], Clofarabine,Clolar, Evoltra, SCHEMBL9040, CHEMBL1750, CLOFARABINE [WHO-DD], MLS003915615, Clofarabine (JAN/USAN/INN), CLOFARABINE [EMA EPAR], 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine, GTPL6802, CHEBI:47311, Clofarabine, >=98% (HPLC), CLOFARABINE [ORANGE BOOK], L01BB06, WDDPHFBMKLOVOX-AYQXTPAHSA-N, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine, HMS2090A07, HMS3413J15, HMS3677J15, BCP23422, HY-A0005, Tox21_112182, AC-274, BDBM50247921, s1218, AKOS005063562, AKOS015919355, Tox21_112182_1, BCP9000540, CCG-264865, CS-0373, DB00631, SAR-393590, NCGC00164553-02, NCGC00164553-05, AS-12958, SMR002530055, BCP0726000280, NS00007160, SW218080-2, D03546, EN300-123437, AB00430247-03, AB00430247-04, AB00430247_06, SR-01000930565, Q5134875, SR-01000930565-3, Z1551900487, 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine, 9h-purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl), 9H-Purine-6-amine,2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-, 2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, 9H-PURIN-6-AMINE, 2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL), (2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 2-chloro-2''-arabino-fluoro-2''-deoxyadenosine, (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine

Name	Clofarabine
PubChem CID	119182
Molecular Weight	303.68g/mol
Synonyms	Clofarabine, 123318-82-1, Clolar, Evoltra, Clofarex, CAFdA, Cl-F-Ara-A, C1-F-Ara-A, clofarabina, clofarabinum, (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine, CHEBI:681569, 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine, UNII-762RDY0Y2H, Cl-F-araA, 762RDY0Y2H, (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol, DTXSID5046437, NSC-759857, (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, DTXCID3026437, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine, MFCD00871077, NSC 759857, Clofarabine [USAN], CLOFARABINE (MART.), CLOFARABINE [MART.], C10H11ClFN5O3, 2-Chloro-9-(2-Deoxy-2-Fluoro-B -D-Arabinofuranosyl)-9h-Purin-6-Amine, (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol, Clolar (TN), CAS-123318-82-1, 2-Cl-2'-F-araA, Clofarabin, Clofarabine [USAN:INN:BAN], NSC606869, NCGC00164553-01, Clofarabine; Clofarex; Clolar; Evoltra; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine, CLOFARABINE [MI], CLOFARABINE [INN], CLOFARABINE [JAN], 2 Chloro 2' fluoroarabino 2' deoxyadenosine, 2-chloro-2'-fluoroarabino-2'-deoxyadenosine, 2 Chloro 2' arabino fluoro 2' deoxyadenosine, CLOFARABINE [VANDF], Clofarabine,Clolar, Evoltra, SCHEMBL9040, CHEMBL1750, CLOFARABINE [WHO-DD], MLS003915615, Clofarabine (JAN/USAN/INN), CLOFARABINE [EMA EPAR], 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine, GTPL6802, CHEBI:47311, Clofarabine, >=98% (HPLC), CLOFARABINE [ORANGE BOOK], L01BB06, WDDPHFBMKLOVOX-AYQXTPAHSA-N, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine, HMS2090A07, HMS3413J15, HMS3677J15, BCP23422, HY-A0005, Tox21_112182, AC-274, BDBM50247921, s1218, AKOS005063562, AKOS015919355, Tox21_112182_1, BCP9000540, CCG-264865, CS-0373, DB00631, SAR-393590, NCGC00164553-02, NCGC00164553-05, AS-12958, SMR002530055, BCP0726000280, NS00007160, SW218080-2, D03546, EN300-123437, AB00430247-03, AB00430247-04, AB00430247_06, SR-01000930565, Q5134875, SR-01000930565-3, Z1551900487, 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine, 9h-purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl), 9H-Purine-6-amine,2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-, 2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, 9H-PURIN-6-AMINE, 2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL), (2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 2-chloro-2''-arabino-fluoro-2''-deoxyadenosine, (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
Drug Type	Small molecule
Formula	C₁₀H₁₁ClFN₅O₃
SMILES	C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)F)Cl)N
InChI	1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChIKey	WDDPHFBMKLOVOX-AYQXTPAHSA-N
CAS Number	123318-82-1
ChEMBL ID	CHEMBL1750
ChEBI ID	CHEBI:681569
TTD ID	D0R5RR
Drug Bank ID	DB00631
KEGG ID	D03546
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Sulforaphane, Clofarabine
Partner Name	Sulforaphane
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Gene Regulation	Up-regulation	Expression	CDKN2A	hsa1029
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	We showed that clofarabine in combination with sulforaphane, a phytochemical from cruciferous vegetables, significantly reactivates DNA methylation-silenced CDKN2A tumour suppressor and inhibits cancer cell growth at a non-invasive breast cancer stage.