| Pair Name | Carvacrol, Fluorouracil | ||
| Phytochemical Name | Carvacrol (PubChem CID: 10364 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
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| Structure of Anticancer Drug |
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| Pair Name | Carvacrol, Fluorouracil | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| Result | Our results suggest that carvacrol can downregulate P-gp expression and combination therapy with carvacrol and 5-FU is considered a novel approach to improve the efficacy of chemotherapeutics in cancer patients with high P-glycoprotein expression. | |||
| No. | Title | Href |
|---|---|---|
| 1 | 5-FU and the dietary flavonoid carvacrol: a synergistic combination that induces apoptosis in MCF-7 breast cancer cells. Med Oncol. 2022 Oct 12;39(12):253. doi: 10.1007/s12032-022-01863-0. | Click |
