| Pair Name | Carnosic acid, Anti-PD-1 antibody | ||
| Phytochemical Name | Carnosic acid (PubChem CID: 65126 ) | ||
| Anticancer drug Name | Anti-PD-1 antibody (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Anti-PD-1 antibody |
| Adverse Reactions | Mouth and tongue sores, dizziness, itchy skin rashes all over the body, increased blood pressure. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Artemisia scoparia; Verbena officinalis |
| Reference | Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022. ref_link |
| Pair Name | Carnosic acid, Anti-PD-1 antibody | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Immunomodulatory | |||
| Gene Regulation | Down-regulation | Expression | CTNNB1 | hsa1499 |
| Down-regulation | Expression | GSK3B | hsa2932 | |
| Down-regulation | Expression | WNT3A | hsa89780 | |
| In Vitro Model | MHCC97-H | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4972 |
| In Vivo Model | MHCC97H cells (4×10⁶ cells/site) were implanted subcutaneously into hip of four- to five-week-old male athymic nude mice. | |||
| Result | CA-NBF combined with anti-PD-1 have stronger immunomodulatory and anticancer effects without increasing biological toxicity. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Carnosic acid nanocluster-based framework combined with PD-1 inhibitors impeded tumorigenesis and enhanced immunotherapy in hepatocellular carcinoma. Funct Integr Genomics. 2024 Jan 6;24(1):5. doi: 10.1007/s10142-024-01286-2. | Click |
