| Name | Calmodulin-dependent protein kinase type II subunit gamma | ||
| UniProt ID | KCC2G_HUMAN | ||
| Gene Name | CAMK2G | ||
| Gene ID | 818 | ||
| Synonyms |
CAMK2G, CAMK, CAMK-II, CAMKG, MRD59
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| Sequence |
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQI LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT VTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL KGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKPQSNNKNSL VSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIE AINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHV HVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 8.A.104.1.12 | ||
| KEGG ID | hsa818 | ||
| TTD ID | T18299 | ||
| Pfam | PF00069; PF03109; PF06293; PF07714; PF08332; PF12680; PF13474; PF13577; PF14534 | ||
| Pair Name | Isorhamnetin, Chloroquine | |||
| Phytochemical | Isorhamnetin | |||
| Drug | Chloroquine | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Regulate Info | Up-regulation | Calmodulin-dependent protein kinase type II subunit gamma | Phosphorylation | |
| Result | Our study highlights the critical role of ROS-mediating CaMKII/Drp1 signaling in the regulation of mitochondrial fission and apoptosis induced by combination of CQ/IH. These findings also suggest that IH could potentially be further developed as a novel chemotherapeutic agent. Furthermore, a combination of IH with classic autophagy/mitophagy inhibitor could represent a novel therapeutic strategy for the treatment of TNBC. | |||
| Pair Name | Phenethyl isothiocyanate, Irinotecan | |||
| Phytochemical | Phenethyl isothiocyanate | |||
| Drug | Irinotecan | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Regulate Info | Up-regulation | Calmodulin-dependent protein kinase type II subunit gamma | Phosphorylation | |
| Result | PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future. | |||
| No. | Title | Href |
|---|---|---|
| 1 | ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine. J Exp Clin Cancer Res. 2019 May 28;38(1):225. doi: 10.1186/s13046-019-1201-4. | Click |
| 2 | Phenethyl isothiocyanate and irinotecan synergistically induce cell apoptosis in colon cancer HCT 116 cells in vitro. Environ Toxicol. 2024 Jan;39(1):457-469. doi: 10.1002/tox.23993. | Click |
