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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name 4'-Hydroxywogonin, Wortmannin
Phytochemical Name 4'-Hydroxywogonin (PubChem CID: 5322078 )
Anticancer drug Name Wortmannin (PubChem CID: 312145 )
Structure of
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2D MOL 3D MOL
Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 152
Ref_1
Pair Name 4'-Hydroxywogonin, Wortmannin
Disease Info [ICD-11: 2B91] Colorectal cancer Investigative
Biological Phenomena Inhibition-->Angiogenesis
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Phosphorylation PIK3CA hsa5290
Down-regulation Expression VEGFA hsa7422
In Vitro Model SW620 Colon adenocarcinoma Homo sapiens (Human) CVCL_0547
Result 4'-HW decreased the viability and reduced angiogenesis in CRC, which was associated with downregulation of VEGF-A expression by disrupting the PI3K/AKT pathway. Our discoveries suggested 4'-HW as a promising anticancer agent against CRC targeting angiogenesis.
03. Reference
No. Title Href
1 4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling. Chem Biol Interact. 2018 Dec 25;296:26-33. doi: 10.1016/j.cbi.2018.09.003. Click
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