| Name | Vitamin D3 receptor | ||
| UniProt ID | VDR_HUMAN | ||
| Gene Name | VDR | ||
| Gene ID | 7421 | ||
| Synonyms |
VDR, NR1I1, PPP1R163
|
||
| Sequence |
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE VFGNEIS |
||
| Pathway Map | MAP LINK | ||
| T.C. Number | 9.B.208.1.1 | ||
| KEGG ID | hsa7421 | ||
| TTD ID | T34234 | ||
| Pfam | PF00104; PF00105 | ||
| Pair Name | Bufalin, 1,25-dihydroxyvitamin D3 | |||
| Phytochemical | Bufalin | |||
| Drug | 1,25-dihydroxyvitamin D3 | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Regulate Info | Up-regulation | Vitamin D3 receptor | Expression | |
| Result | The Na(+),K(+)-ATPase inhibitor bufalin modulates VDR function through several mechanisms, including Erk MAP kinase activation and increased nuclear VDR expression. | |||
