| Name | DNA topoisomerase 1 | ||
| UniProt ID | TOP1_HUMAN | ||
| Gene Name | TOP1 | ||
| Gene ID | 7150 | ||
| Synonyms |
TOP1, TOPI
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| Sequence |
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 1.A.110.1.1; 1.A.110.1.2; 1.A.110.1.5 | ||
| KEGG ID | hsa7150 | ||
| TTD ID | T09826 | ||
| Pfam | PF01028; PF02919; PF14370 | ||
| Pair Name | Epigallocatechin gallate, Irinotecan | |||
| Phytochemical Name | Epigallocatechin gallate | |||
| Anticancer drug Name | Irinotecan | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Regulate Info | Down-regulation | DNA topoisomerase 1 | Expression | |
| Result | EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells | |||
