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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Saikosaponin A, Docetaxel
Phytochemical Name Saikosaponin A (PubChem CID: 167928 )
Anticancer drug Name Docetaxel (PubChem CID: 148124 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 244
Ref_1
Pair Name Saikosaponin A, Docetaxel
Disease Info [ICD-11: 2C82] Prostate cancer Investigative
Biological Phenomena Induction-->Autophagy
Gene Regulation Down-regulation Expression AKT1 hsa207
Down-regulation Expression MAP1LC3A hsa84557
Up-regulation Expression MAP1LC3B hsa81631
Down-regulation Expression SQSTM1 hsa8878
In Vitro Model LNCaP Prostate carcinoma Homo sapiens (Human) CVCL_0395
PC-3 Prostate carcinoma Homo sapiens (Human) CVCL_0035
DU145 Prostate carcinoma Homo sapiens (Human) CVCL_0105
L-02 Papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_6926
HEK293T Healthy Homo sapiens (Human) CVCL_0063
WPMY-1 Healthy Homo sapiens (Human) CVCL_3814
In Vivo Model PC-3 cells (2×10⁶) were injected subcutaneously into the right flank of each mouse.
Result SSA is posed as a novel QCCs-eradicating agent by aggravating autophagy in QCCs. In combination with the current therapy, SSA has potential to improve treatment effectiveness and to prevent cancer recurrence.
03. Reference
No. Title Href
1 Saikosaponin A enhances Docetaxel efficacy by selectively inducing death of dormant prostate cancer cells through excessive autophagy. Cancer Lett. 2023 Feb 1;554:216011. doi: 10.1016/j.canlet.2022.216011. Click
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