| Name | Threonine-protein kinase STK11 | ||
| UniProt ID | STK11_HUMAN | ||
| Gene Name | STK11 | ||
| Gene ID | 6794 | ||
| Synonyms |
STK11, LKB1, PJS, hLKB1
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| Sequence |
MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY
GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA SSKIRRLSACKQQ |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa6794 | ||
| Pfam | PF00069; PF03109; PF06293; PF07714; PF14531 | ||
| Pair Name | Capsaicin, Docetaxel | |||
| Phytochemical | Capsaicin | |||
| Drug | Docetaxel | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Regulate Info | Up-regulation | Threonine-protein kinase STK11 | Phosphorylation | |
| Result | We showed that the synergistic anti-proliferative effect may be attributed to two independent effects: Inhibition of the PI3K/Akt/mTOR signaling pathway by one side, and AMPK activation by the other. In vivo experiments confirmed the synergistic effects of docetaxel and capsaicin in reducing the tumor growth of PC3 cells. | |||
