| Pair Name | Rhein, Calphostin c | ||
| Phytochemical Name | Rhein (PubChem CID: 10168 ) | ||
| Anticancer drug Name | Calphostin c (PubChem CID: 2533 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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3D
MOL
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| Pair Name | Rhein, Calphostin c | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | XIAP | hsa331 |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| Result | Data suggest that rottlerin affects mitochondrial function independent of PKC delta, thereby sensitizing cells to TRAIL, and that mitochondria constitute an important target in overcoming inherent resistance to TRAIL in colon carcinomas. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. Cancer Res. 2003 Aug 15;63(16):5118-25. | Click |
