polyhydroxyflavan-3-ol, proanthocyanidin, Zangrado
| Name | Proanthocyanidin | ||
| PubChem CID | 108065 | ||
| Molecular Weight | 592.5g/mol | ||
| Synonyms |
polyhydroxyflavan-3-ol, proanthocyanidin, Zangrado |
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| Formula | C₃₁H₂₈O₁₂ | ||
| SMILES | COC1=C(C=C(C=C1O)C2C(CC3=C(O2)C(=C(C=C3O)O)C4C(C(OC5=CC(=CC(=C45)O)O)C6=CC=C(C=C6)O)O)O)O | ||
| InChI | 1S/C31H28O12/c1-41-31-20(37)6-13(7-21(31)38)28-22(39)10-16-17(34)11-19(36)25(30(16)43-28)26-24-18(35)8-15(33)9-23(24)42-29(27(26)40)12-2-4-14(32)5-3-12/h2-9,11,22,26-29,32-40H,10H2,1H3/t22-,26-,27-,28?,29-/m1/s1 | ||
| InChIKey | JPFCOVZKLAXXOE-XBNSMERZSA-N | ||
| CAS Number | 18206-61-6 | ||
| Herb ID | HBIN040742 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | DaoGuaCao | ||
| Use Part | Whole herb | ||
| Flavor | Slightly bitter | ||
| Meridian Tropism | Liver; Large Intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Polypodiales
-->Family: Aspleniaceae
-->Genus: Asplenium
-->Species: Asplenium trichomanes
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| Pair Name | Proanthocyanidin, Histone deacetylase inhibitor | |||
| Partner Name | Histone deacetylase inhibitor | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | MMRN1 | hsa22915 |
| In Vitro Model | T-47D | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0553 |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| Result | Their synergism may be closely related to the steroid biosynthesis and extracellular matrix (ECM) receptor interaction pathways. PA + Chi can synergistically inhibit breast cancer cell growth and proliferation, and promote apoptosis. These effects may be related to steroid biosynthesis or the ECM receptor pathway. | |||
