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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Pixinol, Cyclophosphamide
Phytochemical Name Pixinol (PubChem CID: 73352321 )
Anticancer drug Name Cyclophosphamide (PubChem CID: 2907 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Cyclophosphamide
Adverse Reactions Myelosuppression, body temperature increased. This was inferred hot nature anticancer drug.
Recommendations Cold: Tephrosia purpurea
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 279
Ref_1
Pair Name Pixinol, Cyclophosphamide
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
Result These results suggest that compound 2e is a promising agent for anti-hepato-carcinoma, and that it also could be used in combination with CTX to increase efficiency and to reduce toxicity.
03. Reference
No. Title Href
1 Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol. Molecules. 2021 Feb 3;26(4):780. doi: 10.3390/molecules26040780. Click
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