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Phytochemical Details

01. General Information

Name	Pancratistatin
PubChem CID	441597
Molecular Weight	325.27g/mol
Synonyms	pancratistatin
Formula	C₁₄H₁₅NO₈
SMILES	C1OC2=C(O1)C(=C3C(=C2)C4C(C(C(C(C4O)O)O)O)NC3=O)O
InChI	1S/C14H15NO8/c16-8-5-3-1-4-13(23-2-22-4)9(17)6(3)14(21)15-7(5)10(18)12(20)11(8)19/h1,5,7-8,10-12,16-20H,2H2,(H,15,21)/t5-,7-,8-,10+,11+,12+/m1/s1
InChIKey	VREZDOWOLGNDPW-ALTGWBOUSA-N
CAS Number	96203-70-2
ChEMBL ID	CHEMBL419335
ChEBI ID	CHEBI:7906
Herb ID	HBIN038757
KEGG ID	C08535
Structure		Download 2D MOL 3D MOL

02. Source Information of Phytochemical

(1) Paythenocissus tricusiordata Warm

Chineses Pinyin	ChangChunTeng
Use Part	Stem-Leaf
Habitat	BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing
Flavor	Pungent, Mildly astringent
Meridian Tropism	Liver, Spleen

(2) Panax pseudo-ginseng Unknown

(3) Panax ginseng Warm

Chineses Pinyin	RenShen
Use Part	Root
Habitat	JiLin, LiaoNing, HeiLongJiang
Flavor	Sweet, Mildly bitter
Meridian Tropism	Spleen, Lung, Heart, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Araliaceae 　　　　　-->Genus: Panax 　　　　　　-->Species: Panax ginseng

(4) Panax ginseng Warm

Chineses Pinyin	RenShenLu
Use Part	Rhizome
Habitat	JiLin, LiaoNing, HeiLongJiang
Flavor	Sweet, Mildly bitter
Meridian Tropism	Stomach, Spleen, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Araliaceae 　　　　　-->Genus: Panax 　　　　　　-->Species: Panax ginseng

(5) Hymenocallis littoralis Warm

Chineses Pinyin	ShuiGuiJiao
Use Part	Leaf
Flavor	Pungent
Meridian Tropism	Liver; Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Amaryllidaceae 　　　　　-->Genus: Hymenocallis 　　　　　　-->Species: Hymenocallis littoralis

03. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Drug(s) whose efficacy can be enhanced by this phytochemical

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Combination Pair ID: 607

Ref_1

Pair Name	Pancratistatin, Tamoxifen
Partner Name	Tamoxifen
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	ROS1	hsa6098
Result	Our results indicate that TAM alone does not induce apoptosis in this cell line, but sensitizes the mitochondria, thereby enhancing the effect of PST exposure. In conclusion, combination of two nongenotoxic compounds offers a novel treatment regime for this notoriously resilient form of skin cancer.

Combination Pair ID: 954

Ref_2

Pair Name	Pancratistatin, Tamoxifen
Partner Name	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Mitochondria-mediated apoptosis
Gene Regulation	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	In combination with the anti-estrogen Tamoxifen, PST had a synergic effect

04. Reference

No.	Title	Href
1	Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound. Melanoma Res. 2011 Feb;21(1):1-11. doi: 10.1097/CMR.0b013e328337abff.	`Click`
2	Synergy of Pancratistatin and Tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria. Cancer Biol Ther. 2008 Mar;7(3):376-84. doi: 10.4161/cbt.7.3.5364.	`Click`