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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Palmatine, Doxorubicin
Phytochemical Name Palmatine (PubChem CID: 19009 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 49
Pair Name Palmatine, Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Proliferation
In Vitro Model MCF-7 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0031
T-47D Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0553
ZR75-1 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0588
Result Our studies suggest that PLT can be a potential candidate agent for preventing and treating breast cancer.
03. Reference
No. Title Href
1 Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts Synergistically and Additively with Doxorubicin. Molecules. 2021 Oct 15;26(20):6253. doi: 10.3390/molecules26206253. Click
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