InterPAD - DETAILS

berbericinine, berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, chloride, berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, iodide, dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (1:1), dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, hydroxide (1:1), o,o-dimethyldemethyleneberberine, palmatine, palmatine cation, palmatine chloride, palmatine hydrochloride, palmatine hydroxide, palmatine iodide, palmatine ion, palmatine sulfate, palmatinium hydroxide, palmitine hydroxide

No.	Title	Href
1	Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts Synergistically and Additively with Doxorubicin. Molecules. 2021 Oct 15;26(20):6253. doi: 10.3390/molecules26206253.	`Click`

No.

Title

Href

Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts Synergistically and Additively with Doxorubicin. Molecules. 2021 Oct 15;26(20):6253. doi: 10.3390/molecules26206253.

Click

Name	Palmatine
PubChem CID	19009
Molecular Weight	352.4g/mol
Synonyms	berbericinine, berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, chloride, berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, iodide, dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (1:1), dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, hydroxide (1:1), o,o-dimethyldemethyleneberberine, palmatine, palmatine cation, palmatine chloride, palmatine hydrochloride, palmatine hydroxide, palmatine iodide, palmatine ion, palmatine sulfate, palmatinium hydroxide, palmitine hydroxide
Formula	C₂₁H₂₂NO₄+
SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC
InChI	1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1
InChIKey	QUCQEUCGKKTEBI-UHFFFAOYSA-N
CAS Number	3486-67-7
ChEMBL ID	CHEMBL206106
ChEBI ID	CHEBI:16096
Herb ID	HBIN038666
KEGG ID	C05315
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	HuangBai
Use Part	Bark
Habitat	ZheJiang, JiangXi, HuBei, GuangXi, SiChuan, GuiZhou, YunNan, Shaanxi
Flavor	Bitter
Meridian Tropism	Kidney, Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Rutaceae 　　　　　-->Genus: Phellodendron 　　　　　　-->Species: Phellodendron chinense

Chineses Pinyin	HuangBai
Use Part	Bark
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, ShanDong, JiangSu, ZheJiang
Flavor	Bitter
Meridian Tropism	Kidney; Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Rutaceae 　　　　　-->Genus: Phellodendron 　　　　　　-->Species: Phellodendron amurense

Pair Name	Palmatine, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Proliferation
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	T-47D	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0553
	ZR75-1	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0588
Result	Our studies suggest that PLT can be a potential candidate agent for preventing and treating breast cancer.