| Name | Fructose-2,6-bisphosphatase 3 | ||
| UniProt ID | F263_HUMAN | ||
| Gene Name | PFKFB3 | ||
| Gene ID | 5209 | ||
| Synonyms |
PFKFB3, IPFK2, PFK2, iPFK-2
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| Sequence |
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa5209 | ||
| TTD ID | T23787 | ||
| Pfam | PF00300; PF00448; PF01591; PF01843; PF06414; PF08433; PF13207; PF13238; PF13671 | ||
| Pair Name | Ginsenoside Rg3, Tamoxifen | |||
| Phytochemical | Ginsenoside Rg3 | |||
| Drug | Tamoxifen | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Regulate Info | Down-regulation | Fructose-2,6-bisphosphatase 3 | Expression | |
| Result | This study highlights the contribution of Rg3 in enhancing the therapeutic efficacy of TAM in breast cancer, and suggests that targeting TAM-resistant PFKFB3 overexpression may represent a promising strategy to improve the response to combination therapy in breast cancer. | |||
