| Name | Oxysterols receptor LXR-beta | ||
| UniProt ID | NR1H2_HUMAN | ||
| Gene Name | NR1H2 | ||
| Gene ID | 7376 | ||
| Synonyms |
NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR
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| Sequence |
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa7376 | ||
| TTD ID | T13714 | ||
| Pfam | PF00104; PF00105; PF17093 | ||
| Pair Name | Triptolide, Carboplatin | |||
| Phytochemical | Triptolide | |||
| Drug | Carboplatin | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Regulate Info | Down-regulation | Oxysterols receptor LXR-beta | Activity | |
| Result | This study reveals the NER inhibitor TPL which has great potential in treating melanoma, either alone or in combination with CBP. | |||
