| Name | Protein NDRG1 | ||
| UniProt ID | NDRG1_HUMAN | ||
| Gene Name | NDRG1 | ||
| Gene ID | 10397 | ||
| Synonyms |
NDRG1, CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
|
||
| Sequence |
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSVHVTLCGTPKGNRPVIL
TYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAE MLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKI SGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIE RPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAK LAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGT RSRSHTSEGAHLDITPNSGAAGNSAGPKSMEVSC |
||
| Pathway Map | MAP LINK | ||
| KEGG ID | hsa10397 | ||
| Pfam | PF00561; PF03096; PF06522; PF12146; PF12697 | ||
| Pair Name | Baicalin, Fluorouracil | |||
| Phytochemical | Baicalin | |||
| Drug | Fluorouracil | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Regulate Info | Up-regulation | Protein NDRG1 | Phosphorylation | |
| Result | These results indicate that HQ and its component baicalin enhance the effect of 5-fluorouracil-based chemotherapy via inhibition of CDK-RB pathway. These findings may provide the rational basis for developing agents that can overcome the development of cellular drug resistance. Video Abstract. | |||
