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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Menadione, Sodium orthovanadate
Phytochemical Name Menadione (PubChem CID: 4055 )
Anticancer drug Name Sodium orthovanadate (PubChem CID: 61671 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 728
Pair Name Menadione, Sodium orthovanadate
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Inhibition-->Cell metastasis
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
Result Our data guarantee further studies to evaluate the in vivo occurrence of D-IDCs, their implications for invasiveness and metastasis and their sensitivity to anticancer drugs.
Combination Pair ID: 727
Pair Name Menadione, Sodium orthovanadate
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
In Vitro Model DBTRG-05MG Anaplastic astrocytoma Homo sapiens (Human) CVCL_1169
Result Our results indicate that M:SO combination is an attractive alternative for glioma treatment that encourages further study. The neutralizing effects of genistein and DTT reveal a possibility for their use in the minimization of potential M:SO systemic toxicity.
03. Reference
No. Title Href
1 Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells. ISRN Pharmacol. 2012;2012:307102. doi: 10.5402/2012/307102. Click
2 Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells. Invest New Drugs. 2012 Aug;30(4):1302-10. doi: 10.1007/s10637-011-9680-y. Click
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