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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name microRNA 15b
UniProt ID /
Gene Name MIR15B
Gene ID 406949
Synonyms
MIR15B, MIRN15B, hsa-mir-15b, miR-15b
Sequence
/
Pathway Map MAP LINK
KEGG ID hsa406949
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 542
Ref_1
Pair Name Sulforaphane, MiR-15b-5p
Phytochemical Sulforaphane
Drug MiR-15b-5p
Disease Info [ICD-11: 2B90.Z] Colon cancer Investigative
Regulate Info Down-regulation microRNA 15b Expression
Result Our data demonstrate that this combined treatment leads to a very high proportion of apoptotic HT-29 cells (over 85%), a value higher than the sum of the values of apoptotic cells obtained after singularly administered regents (either SFN or R8-PNA-a15b).
03. Reference
No. Title Href
1 High Levels of Apoptosis Are Induced in the Human Colon Cancer HT-29 Cell Line by Co-Administration of Sulforaphane and a Peptide Nucleic Acid Targeting miR-15b-5p. Nucleic Acid Ther. 2020 Jun;30(3):164-174. doi: 10.1089/nat.2019.0825. Click
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