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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Isoliquiritigenin, Cisplatin
Phytochemical Name Isoliquiritigenin (PubChem CID: 638278 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Cisplatin
Adverse Reactions Myelosuppression, dry mouth and throat, fever, dry stools. This was inferred hot nature anticancer drug.
Recommendations Cold: Anemarrhena asphodeloides; Urena lobataL; Artemisia scoparia; Swertia mussotii; Swertia pseudochinensis; Gentiana manshurica; Gossampinus malabarica; Pyrrosia sheareri; Pyrrosia sheareri; Iris domestica; Gentiana scabra; Pyrrosia sheareri; Pyrrosia petiolosa
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.  ref_link
Combination Pair ID: 857
Pair Name Isoliquiritigenin, Cisplatin
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->DNA damage
In Vitro Model CT26 Mouse colon adenocarcinoma Mus musculus (Mouse) CVCL_7254
In Vivo Model The CT-26 mouse colon cancer cells (2×10⁶ cells in 0.1 mL PBS) cultured in DMEM with 10% FBS were subcutaneously injected into the right flanks of the BALB/c male mice.
Result Supplementation with ISL may be an effective approach to counteracting the side effects of cisplatin therapy in cancer patients.
03. Reference
No. Title Href
1 Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. J Pharmacol Sci. 2008 Mar;106(3):444-51. doi: 10.1254/jphs.fp0071498. Click
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