Pair Name | Isoliquiritigenin, Cisplatin | ||
Phytochemical Name | Isoliquiritigenin (PubChem CID: 638278 ) | ||
Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Drug Name | Cisplatin |
Adverse Reactions | Myelosuppression, dry mouth and throat, fever, dry stools. This was inferred hot nature anticancer drug. |
Recommendations | Cold: Anemarrhena asphodeloides; Urena lobataL; Artemisia scoparia; Swertia mussotii; Swertia pseudochinensis; Gentiana manshurica; Gossampinus malabarica; Pyrrosia sheareri; Pyrrosia sheareri; Iris domestica; Gentiana scabra; Pyrrosia sheareri; Pyrrosia petiolosa |
Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
Pair Name | Isoliquiritigenin, Cisplatin | |||
Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
Biological Phenomena | Induction-->DNA damage | |||
In Vitro Model | CT26 | Mouse colon adenocarcinoma | Mus musculus (Mouse) | CVCL_7254 |
In Vivo Model | The CT-26 mouse colon cancer cells (2×10⁶ cells in 0.1 mL PBS) cultured in DMEM with 10% FBS were subcutaneously injected into the right flanks of the BALB/c male mice. | |||
Result | Supplementation with ISL may be an effective approach to counteracting the side effects of cisplatin therapy in cancer patients. |
No. | Title | Href |
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1 | Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. J Pharmacol Sci. 2008 Mar;106(3):444-51. doi: 10.1254/jphs.fp0071498. | Click |