| Name | Insulin-like growth factor-binding protein 1 | ||
| UniProt ID | IBP1_HUMAN | ||
| Gene Name | IGFBP1 | ||
| Gene ID | 3484 | ||
| Synonyms |
IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1
|
||
| Sequence |
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCC
PMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGS PESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIEL YRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIP GSPEIRGDPNCQIYFNVQN |
||
| Pathway Map | MAP LINK | ||
| KEGG ID | hsa3484 | ||
| TTD ID | T15048 | ||
| Pfam | PF00086; PF00219 | ||
| Pair Name | Solamargine, Gefitinib | |||
| Phytochemical | Solamargine | |||
| Drug | Gefitinib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Regulate Info | Up-regulation | Insulin-like growth factor-binding protein 1 | Expression | |
| Result | We confirmed that SM significantly enhanced the anticancer effect of EGFR-TKIs by regulating the MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway. This study unravels a novel mechanism and suggests a new potential NSCLC-associated therapy. | |||
