Pair Name	Camptothecin, Camptosar
Phytochemical	Camptothecin
Drug	Camptosar
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	High mobility group protein B1		Expression
Result	Camptothesome Potentiates PD-L1 Immune Checkpoint Blockade for Improved Metastatic Triple-Negative Breast Cancer Immunochemotherapy

Pair Name	Lycorine, Bortezomib
Phytochemical	Lycorine
Drug	Bortezomib
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Down-regulation	High mobility group protein B1		Expression
Result	We observed higher HMGB1 expression in bortezomib resistant cells and the combination of bortezomib plus lycorine was highly efficient in vitro and in vivo myeloma models as well as in re-sensitizing resistant cells to bortezomib. These observations indicate lycorine as an effective autophagy inhibitor and reveal that lycorine alone or in combination with bortezomib is a potential therapeutic strategy.

Pair Name	Morin Hydrate, Cisplatin
Phytochemical	Morin Hydrate
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	High mobility group protein B1		Expression
Result	Our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.

Pair Name	Shikonin, Anti-mouse PD-1
Phytochemical	Shikonin
Drug	Anti-mouse PD-1
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	High mobility group protein B1		Expression
Result	Our study elucidated the potential role of 'Shikonin-PKM2-ROS-Hsp70' axis in the promotion of efficacy of PD-1 blockade in CRC treatments, providing a potential strategy and targets for improving the efficacy of PD-1 blockade in colorectal cancer.

Pair Name	Morin Hydrate, Cisplatin
Phytochemical	Morin Hydrate
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	High mobility group protein B1		Expression
Result	The combination of Morin hydrate with cisplatin may be a promising therapeutic strategy to enhance the efficacy of conventional chemotherapeutic drugs.