| Name | Histone deacetylase 3 | ||
| UniProt ID | HDAC3_HUMAN | ||
| Gene Name | HDAC3 | ||
| Gene ID | 8841 | ||
| Synonyms |
HDAC3, HD3, KDAC3, RPD3, RPD3-2
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| Sequence |
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN DKESDVEI |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa8841 | ||
| TTD ID | T05090 | ||
| Pfam | PF00850 | ||
| Pair Name | Betulinic acid, Imatinib | |||
| Phytochemical | Betulinic acid | |||
| Drug | Imatinib | |||
| Disease Info | [ICD-11: 2B33.2] | Chronic myeloid leukemia | Investigative | |
| Regulate Info | Down-regulation | Histone deacetylase 3 | Expression | |
| Result | Our findings demonstrated that HDAC3 is an essential factor in BCR-ABL1 kinase-independent IM resistance, and that BA in combination with IM may be a novel treatment strategy for overcoming IM resistance in CML. | |||
