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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name H19 imprinted maternally expressed transcript
UniProt ID /
Gene Name H19
Gene ID 283120
Synonyms
ASM, BWS, WT2, ASM1, GMRSP, D11S813E, MIR675HG, LINC00008, NCRNA00008
Sequence
/
Pathway Map MAP LINK
TTD ID T82849
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 234
Ref_1
Pair Name Beta-Elemene, Erlotinib
Phytochemical Beta-Elemene
Drug Erlotinib
Disease Info [ICD-11: 2C25.Z] Lung cancer Investigative
Regulate Info Up-regulation H19 imprinted maternally expressed transcript Expression
Result Our data showed that β-elemene combined with erlotinib could enhance sensitivity to EGFR-TKIs through induction of ferroptosis via H19 in primary EGFR-TKI-resistant lung cancer, providing a promising strategy to overcome EGFR-TKI resistance in NSCLC patients.
03. Reference
No. Title Href
1 β-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer. Pharmacol Res. 2023 May;191:106739. doi: 10.1016/j.phrs.2023.106739. Click
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