| Name | Glutathione S-transferase P | ||
| UniProt ID | GSTP1_HUMAN | ||
| Gene Name | GSTP1 | ||
| Gene ID | 2950 | ||
| Synonyms |
GSTP1, DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
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| Sequence |
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY VGRLSARPKLKAFLASPEYVNLPINGNGKQ |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa2950 | ||
| TTD ID | T21669 | ||
| Pfam | PF00043; PF02798; PF13409; PF13410; PF14497 | ||
| Pair Name | Glucosinalbate, Doxorubicin | |||
| Phytochemical | Glucosinalbate | |||
| Drug | Doxorubicin | |||
| Disease Info | [ICD-11: 2C90] | Ehrlich ascites carcinoma | Investigative | |
| Regulate Info | Up-regulation | Glutathione S-transferase P | Expression | |
| Result | The present study clearly suggested therapeutic benefit of I3C in combination with DOX by augmenting anticancer efficacy and diminishing toxicity to the host. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway. Chem Biol Interact. 2018 Jun 25;290:19-36. doi: 10.1016/j.cbi.2018.05.005. | Click |
