Pair Name	Escin, Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Ferroptosis
Gene Regulation	Down-regulation	Expression	GPX4	hsa2879
	Down-regulation	Expression	G6PD	hsa2539
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vivo Model	MDA-MB-231 cells (2.5×10⁶ cells per mouse) stably expressing sh-NC and sh-G6PD were established.When the tumor grew to approximately 60 mm3, 2 mg/kg Escin was intraperitoneally injected with normal saline as the control.
Result	Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin