InterPAD - DETAILS

EFLORNITHINE, 70052-12-9, dfmo, Difluoromethylornithine, Ornidyl, 2-(Difluoromethyl)ornithine, 2,5-diamino-2-(difluoromethyl)pentanoic acid, Eflornithinum, Eflornitina, Vaniqa, 67037-37-0, alpha-Difluoromethylornithine, 2-(Difluoromethyl)-DL-ornithine, Difluromethylornithine, N-Difluoromethylornithine, alpha-(Difluoromethyl)-DL-ornithine, DFMO (growth regulator), Ornithine, 2-(difluoromethyl)-, Eflornithinum [Latin], DL-alpha-(Difluoromethyl)ornithine, DL-Ornithine, 2-(difluoromethyl)-, Eflornithine free base, RMI 71782, CCRIS 3295, UNII-ZQN1G5V6SR, ZQN1G5V6SR, BRN 2250529, Eflornithine (INN), CHEBI:41948, alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid, HSDB 7923, DL-.alpha.-Difluoromethylornithine, 70052-12-9 (free base), RFI 7178, MDL 71782, CHEMBL830, DFMO HCl, 70050-56-5, DTXSID3020467, 2-(difluoromethyl)ornithine (DMFO), Iwilfin, NSC337250, Eflornithinum (Latin), Eflornitina [Spanish], EFLORNITHINE [INN], 2,5-diamino-2-(difluoromethyl)pentanoic acid., .alpha.-DFMO HCl, Eflornithine [INN:BAN], (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid, DL-alpha-Difluoromethylornithine, DL-Ornithine, monohydrochloride, alpha-DFMO, NSC-337250, L-DFMO;L-RMI71782;L-alpha-difluoromethylornithine, L-alpha-Difluoromethylornithine, (-)-2-Difluoromethylornithine, SR-01000076229, (RS)-eflornithine, EFLORNITHINE [MI], alpha difluoromethylornithine, EFLORNITHINE [VANDF], Lopac0_000429, SCHEMBL26327, alpha-difluoromethyl ornithine, alpha Difluoromethyl Ornithine, DTXCID70467, EFLORNITHINE [WHO-DD], Ornithine, alpha-Difluoromethyl, GTPL5176, 2-(difluoromethyl)-L-ornithine, DL alpha Difluoromethylornithine, EFLORNITHINE [EMA EPAR], alpha-difluoromethyl-dl-ornithine, D11AX16, P01CX03, BCP10516, HY-B0744, BDBM50028197, HSCI1_000267, MFCD00221766, .ALPHA.-DIFLUOROMETHYLORNITHINE, AKOS006281180, CCG-204521, DB06243, SDCCGSBI-0050414.P002, NCGC00015316-02, NCGC00015316-03, NCGC00015316-06, NCGC00015316-15, NCGC00162152-01, 2-difluoromethyl-2,5-diaminopentanoic acid, DB-055371, FT-0630795, FT-0720946, FT-0775156, NS00006082, C07997, D07883, EN300-150187, L-DFMO;L-RMI71782;L--difluoromethylornithine, A936641, Q424751, SR-01000076229-10

Name	Eflornithine
PubChem CID	3009
Molecular Weight	182.17g/mol
Synonyms	EFLORNITHINE, 70052-12-9, dfmo, Difluoromethylornithine, Ornidyl, 2-(Difluoromethyl)ornithine, 2,5-diamino-2-(difluoromethyl)pentanoic acid, Eflornithinum, Eflornitina, Vaniqa, 67037-37-0, alpha-Difluoromethylornithine, 2-(Difluoromethyl)-DL-ornithine, Difluromethylornithine, N-Difluoromethylornithine, alpha-(Difluoromethyl)-DL-ornithine, DFMO (growth regulator), Ornithine, 2-(difluoromethyl)-, Eflornithinum [Latin], DL-alpha-(Difluoromethyl)ornithine, DL-Ornithine, 2-(difluoromethyl)-, Eflornithine free base, RMI 71782, CCRIS 3295, UNII-ZQN1G5V6SR, ZQN1G5V6SR, BRN 2250529, Eflornithine (INN), CHEBI:41948, alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid, HSDB 7923, DL-.alpha.-Difluoromethylornithine, 70052-12-9 (free base), RFI 7178, MDL 71782, CHEMBL830, DFMO HCl, 70050-56-5, DTXSID3020467, 2-(difluoromethyl)ornithine (DMFO), Iwilfin, NSC337250, Eflornithinum (Latin), Eflornitina [Spanish], EFLORNITHINE [INN], 2,5-diamino-2-(difluoromethyl)pentanoic acid., .alpha.-DFMO HCl, Eflornithine [INN:BAN], (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid, DL-alpha-Difluoromethylornithine, DL-Ornithine, monohydrochloride, alpha-DFMO, NSC-337250, L-DFMO;L-RMI71782;L-alpha-difluoromethylornithine, L-alpha-Difluoromethylornithine, (-)-2-Difluoromethylornithine, SR-01000076229, (RS)-eflornithine, EFLORNITHINE [MI], alpha difluoromethylornithine, EFLORNITHINE [VANDF], Lopac0_000429, SCHEMBL26327, alpha-difluoromethyl ornithine, alpha Difluoromethyl Ornithine, DTXCID70467, EFLORNITHINE [WHO-DD], Ornithine, alpha-Difluoromethyl, GTPL5176, 2-(difluoromethyl)-L-ornithine, DL alpha Difluoromethylornithine, EFLORNITHINE [EMA EPAR], alpha-difluoromethyl-dl-ornithine, D11AX16, P01CX03, BCP10516, HY-B0744, BDBM50028197, HSCI1_000267, MFCD00221766, .ALPHA.-DIFLUOROMETHYLORNITHINE, AKOS006281180, CCG-204521, DB06243, SDCCGSBI-0050414.P002, NCGC00015316-02, NCGC00015316-03, NCGC00015316-06, NCGC00015316-15, NCGC00162152-01, 2-difluoromethyl-2,5-diaminopentanoic acid, DB-055371, FT-0630795, FT-0720946, FT-0775156, NS00006082, C07997, D07883, EN300-150187, L-DFMO;L-RMI71782;L--difluoromethylornithine, A936641, Q424751, SR-01000076229-10
Drug Type	Small molecule
Formula	C₆H₁₂F₂N₂O₂
SMILES	C(CC(C(F)F)(C(=O)O)N)CN
InChI	1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)
InChIKey	VLCYCQAOQCDTCN-UHFFFAOYSA-N
CAS Number	1069-31-4
ChEMBL ID	CHEMBL830
ChEBI ID	CHEBI:41948
TTD ID	D0X7JR
Drug Bank ID	DB06243
KEGG ID	C07997
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Thymoquinone, Eflornithine
Partner Name	Thymoquinone
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	DNMT1	hsa1786
	Down-regulation	Expression	HDAC1	hsa3065
	Down-regulation	Expression	UHRF1	hsa29128
In Vitro Model	Jurkat	Childhood T acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_0065
Result	These results suggest that the combination of DFMO and TQ could be a promising new strategy for the treatment of human acute T lymphoblastic leukemia by targeting the epigenetic code.