InterPAD - DETAILS

Dibenzoylmethane, 120-46-7, 1,3-Diphenylpropane-1,3-dione, 1,3-DIPHENYL-1,3-PROPANEDIONE, 1,3-Propanedione, 1,3-diphenyl-, 2-Benzoylacetophenone, Phenyl phenacyl ketone, Rhodiastab 83, omega-Benzoylacetophenone, Dibenzoyl-methane, 1,3-Diphenyl-propane-1,3-dione, .omega.-Benzoylacetophenone, NSC 6266, MFCD00003085, .gamma.-hydroxychalkone, ANS7ME8OKC, NSC-6266, DTXSID3041247, CHEBI:75417, Karenzu DK2, dibenzoyl methane, UNII-ANS7ME8OKC, EINECS 204-398-9, BRN 0514910, AI3-19022, CCRIS 8445, Karenzu DK 2, 1, 1,3-diphenyl-, Spectrum2_000038, Spectrum3_001950, EC 204-398-9, SCHEMBL39582, BSPBio_003550, DIBENZOYLMETHANE [MI], MLS002695996, SPECTRUM1505311, SPBio_000135, CHEMBL371523, 1,3-diphenyl-1,3-propandione, 1,3-diphenyl-1,3-propanedion, DIBENZOYLMETHANE [MART.], DTXCID1021247, BDBM22727, KBio3_002841, NSC6266, 1,3-Diphenyl-Propan-1,3-Dion, GLXC-10191, HMS3091A20, STR01439, Tox21_300686, AC7872, CCG-40047, STK372683, AKOS000119639, CS-W010447, HY-W009731, 1,3-Diphenyl-1,3-propanedione, 98%, UPCMLD0ENAT5883819:001, NCGC00095298-01, NCGC00095298-02, NCGC00095298-03, NCGC00095298-04, NCGC00254594-01, AC-11379, CAS-120-46-7, SMR001253722, SY014045, PHENYL-.ALPHA.-HYDROXYSTYRYL KETONE, DB-041558, DIPHENYL-1,3-PROPANEDIONE, 1,3-, AM20020283, D0910, FT-0624640, NS00001692, EN300-20083, Dibenzoylmethane 1,3-Diphenyl-1,3-propanedione, Q5272260, W-108476, BRD-K01555864-001-02-8, F0001-0329, Z104476748

No.	Title	Href
1	Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells. Food Funct. 2018 Apr 25;9(4):2398-2408. doi: 10.1039/c7fo01983a.	`Click`

No.

Title

Href

Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells. Food Funct. 2018 Apr 25;9(4):2398-2408. doi: 10.1039/c7fo01983a.

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Name	Dibenzoylmethane
PubChem CID	8433
Molecular Weight	224.25g/mol
Synonyms	Dibenzoylmethane, 120-46-7, 1,3-Diphenylpropane-1,3-dione, 1,3-DIPHENYL-1,3-PROPANEDIONE, 1,3-Propanedione, 1,3-diphenyl-, 2-Benzoylacetophenone, Phenyl phenacyl ketone, Rhodiastab 83, omega-Benzoylacetophenone, Dibenzoyl-methane, 1,3-Diphenyl-propane-1,3-dione, .omega.-Benzoylacetophenone, NSC 6266, MFCD00003085, .gamma.-hydroxychalkone, ANS7ME8OKC, NSC-6266, DTXSID3041247, CHEBI:75417, Karenzu DK2, dibenzoyl methane, UNII-ANS7ME8OKC, EINECS 204-398-9, BRN 0514910, AI3-19022, CCRIS 8445, Karenzu DK 2, 1, 1,3-diphenyl-, Spectrum2_000038, Spectrum3_001950, EC 204-398-9, SCHEMBL39582, BSPBio_003550, DIBENZOYLMETHANE [MI], MLS002695996, SPECTRUM1505311, SPBio_000135, CHEMBL371523, 1,3-diphenyl-1,3-propandione, 1,3-diphenyl-1,3-propanedion, DIBENZOYLMETHANE [MART.], DTXCID1021247, BDBM22727, KBio3_002841, NSC6266, 1,3-Diphenyl-Propan-1,3-Dion, GLXC-10191, HMS3091A20, STR01439, Tox21_300686, AC7872, CCG-40047, STK372683, AKOS000119639, CS-W010447, HY-W009731, 1,3-Diphenyl-1,3-propanedione, 98%, UPCMLD0ENAT5883819:001, NCGC00095298-01, NCGC00095298-02, NCGC00095298-03, NCGC00095298-04, NCGC00254594-01, AC-11379, CAS-120-46-7, SMR001253722, SY014045, PHENYL-.ALPHA.-HYDROXYSTYRYL KETONE, DB-041558, DIPHENYL-1,3-PROPANEDIONE, 1,3-, AM20020283, D0910, FT-0624640, NS00001692, EN300-20083, Dibenzoylmethane 1,3-Diphenyl-1,3-propanedione, Q5272260, W-108476, BRD-K01555864-001-02-8, F0001-0329, Z104476748
Drug Type	Small molecule
Formula	C₁₅H₁₂O₂
SMILES	C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2
InChI	1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2
InChIKey	NZZIMKJIVMHWJC-UHFFFAOYSA-N
CAS Number	120-46-7
ChEMBL ID	CHEMBL371523
ChEBI ID	CHEBI:75417
TTD ID	D02BDL
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Phenethyl isothiocyanate, Dibenzoylmethane
Partner Name	Phenethyl isothiocyanate
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Activity	CDH13	hsa1012
In Vitro Model	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	DU145	Prostate carcinoma	Homo sapiens (Human)	CVCL_0105
	VCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_2235
In Vivo Model	For a xenograft model, 2×10⁶ VCaP cells per 0.1 ml suspended in a mixture of Matrigel and RPMI 1640 medium (1 : 1) were injected subcutaneously into the back of the mice.
Result	Our results indicate that administration of DBM and PEITC in combination may be an effective strategy for inhibiting/delaying the progression of prostate cancer to androgen independence.