| Pair Name | Delta-Tocotrienol, Bortezomib | ||
| Phytochemical Name | Delta-Tocotrienol (PubChem CID: 5282350 ) | ||
| Anticancer drug Name | Bortezomib (PubChem CID: 387447 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Delta-Tocotrienol, Bortezomib | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | NFE2L1 | hsa4779 |
| Down-regulation | Expression | POMP | KEGG ID N.A. | |
| Down-regulation | Expression | PSMA7 | KEGG ID N.A. | |
| Down-regulation | Expression | PSMB7 | KEGG ID N.A. | |
| Down-regulation | Expression | PSMC4 | KEGG ID N.A. | |
| In Vitro Model | NCI-H2452 | Pleural biphasic mesothelioma | Homo sapiens (Human) | CVCL_1553 |
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0480 | |
| A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 | |
| Result | These findings suggested that the inactivation of NFE2L1 by T3, TOS, and T3E is essential to potentiate the cytotoxic effect of the proteasome inhibitor, BTZ, in solid cancers. | |||
| No. | Title | Href |
|---|---|---|
| 1 | α-Tocotrienol and Redox-Silent Analogs of Vitamin E Enhances Bortezomib Sensitivity in Solid Cancer Cells through Modulation of NFE2L1. Int J Mol Sci. 2023 May 27;24(11):9382. doi: 10.3390/ijms24119382. | Click |
