| Name | Dihydrofolate reductase | ||
| UniProt ID | DYR_HUMAN | ||
| Gene Name | DHFR | ||
| Gene ID | 1719 | ||
| Synonyms |
DHFR, DHFR1, DHFRP1, DYR
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| Sequence |
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF EVYEKND |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa1719 | ||
| TTD ID | T17345 | ||
| Pfam | PF00186 | ||
| Pair Name | Baicalin, Fluorouracil | |||
| Phytochemical | Baicalin | |||
| Drug | Fluorouracil | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Regulate Info | Down-regulation | Dihydrofolate reductase | Expression | |
| Result | These results indicate that HQ and its component baicalin enhance the effect of 5-fluorouracil-based chemotherapy via inhibition of CDK-RB pathway. These findings may provide the rational basis for developing agents that can overcome the development of cellular drug resistance. Video Abstract. | |||
