Pair Name	Crocin, Metformin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	MMP9	hsa4318
In Vitro Model	4T1	Malignant neoplasms of the mouse mammary gland	Mus musculus (Mouse)	CVCL_0125
In Vivo Model	1×10⁶ 4T1 cells suspended in 0.2 ml phosphate-buffered saline and inoculated into the left dorsal flank regions of the mice.
Result	These findings suggest that a combination of crocin and metformin could serve as a novel therapeutic approach to enhance the effectiveness of metastatic breast cancer therapy.