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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Coptisine, Cisplatin
Phytochemical Name Coptisine (PubChem CID: 72322 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Combination Pair ID: 50
Pair Name Coptisine, Cisplatin
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in sub-G1 phase
In Vitro Model NCI-N87 Gastric tubular adenocarcinoma Homo sapiens (Human) CVCL_1603
In Vivo Model One hour after fertilization, zebrafish embryos were selected—only fertilized and completely transparent embryos were transferred to 48 well plates. In each well, at least 3 embryos were kept in the 400 µL of medium without, or supplemented with, different doses of 11 (12.5, 25, 62.5, 125, 187.5 or 250 µg/mL) (39.02, 78.04, 195.12, 390.24, 585.37 or 780.49 µM).
Result Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells
03. Reference
No. Title Href
1 Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells. Int J Mol Sci. 2022 Sep 7;23(18):10330. doi: 10.3390/ijms231810330. Click
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