| Pair Name | Camptothecin, Doxorubicin | ||
| Phytochemical Name | Camptothecin (PubChem CID: 24360 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Camptothecin, Doxorubicin | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | CTNNB1 | hsa1499 |
| In Vitro Model | 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 |
| BT-474 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0179 | |
| In Vivo Model | Tumor inoculation was achieved by subcutaneously injecting 5×10⁴ 4T1 cells in the abdominal mammary gland of female BALB/c mice in order to prevent interference with normal bodily functions. | |||
| Result | Camptothecin-doxorubicin combinations showed synergistic antitumor acitivity. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic antitumor activity of camptothecin-doxorubicin combinations and their conjugates with hyaluronic acid. J Control Release. 2015 Jul 28;210:198-207. doi: 10.1016/j.jconrel.2015.04.031. | Click |
