| Name | Cyclic AMP-responsive element-binding protein 1 | ||
| UniProt ID | CREB1_HUMAN | ||
| Gene Name | CREB1 | ||
| Gene ID | 1385 | ||
| Synonyms |
CREB1, CREB, CREB-1
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| Sequence |
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR VAVLENQNKTLIEELKALKDLYCHKSD |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa1385 | ||
| TTD ID | T92098 | ||
| Pfam | PF00170; PF02173; PF03131; PF07716; PF08687 | ||
| Pair Name | Berbamine, Aspirin | |||
| Phytochemical | Berbamine | |||
| Drug | Aspirin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Down-regulation | Cyclic AMP-responsive element-binding protein 1 | Phosphorylation | |
| Result | These data demonstrate that the regulation of cAMP-PKA-CREB/ATF1 signaling represents a noncanonical function of CPS1. Targeting the PKA-CREB/ATF1 axis may be a strategy to improve the therapeutic effects of aspirin on HCC. | |||
