| Pair Name | Betulin, Sorafenib | ||
| Phytochemical Name | Betulin (PubChem CID: 72326 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Betulin, Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Glycolysis | |||
| Gene Regulation | Up-regulation | Expression | SREBF1 | hsa6720 |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0336 | |
| SMMC-7721 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0534 | |
| BEL-7402 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_5492 | |
| MHCC97-L | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4973 | |
| MHCC97-H | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4972 | |
| In Vivo Model | HCC cells were cultured, and the cells were injected subcutaneously into nude mice, antitumor agents were intragastrically administered 2–3 days after injection of HCC cells. | |||
| Result | Our data show that SREBP-1 inhibition facilitated the antitumor effects of Sorafenib on HCC cells and xenograft tumors. | |||
| No. | Title | Href |
|---|---|---|
| 1 | SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity. Cell Death Dis. 2019 Sep 11;10(9):672. doi: 10.1038/s41419-019-1884-7. | Click |
