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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Renin receptor
UniProt ID RENR_HUMAN
Gene Name ATP6AP2
Gene ID 10159
Synonyms
ATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, CDG2R, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS
Sequence
MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSW
PGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEE
TPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVD
LLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKIL
VDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYN
FEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD
Pathway Map MAP LINK
T.C. Number 8.A.80.1.1
KEGG ID hsa10159
Pfam PF01663; PF07850
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 220
Pair Name Toosendanin, Camptothecin
Phytochemical Toosendanin
Drug Camptothecin
Disease Info [ICD-11: 2C77] Cervical cancer Investigative
Regulate Info Down-regulation Renin receptor Activity
Result These results suggest that toosendanin has the potential to be developed into an anti-cancer drug by blocking chemotherapy-induced protective autophagy.
03. Reference
No. Title Href
1 Toosendanin, a novel potent vacuolar-type H+-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy. Int J Biol Sci. 2022 Mar 28;18(7):2684-2702. doi: 10.7150/ijbs.71041. Click
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