| Name | Cyclic AMP-dependent transcription factor ATF-1 | ||
| UniProt ID | ATF1_HUMAN | ||
| Gene Name | ATF1 | ||
| Gene ID | 466 | ||
| Synonyms |
ATF1, EWS-ATF1, FUS/ATF-1, TREB36
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| Sequence |
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR
RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC LENRVAVLENQNKTLIEELKTLKDLYSNKSV |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 8.A.98.1.8 | ||
| KEGG ID | hsa466 | ||
| Pfam | PF00170; PF02173; PF03131; PF07716; PF08687 | ||
| Pair Name | Berbamine, Aspirin | |||
| Phytochemical | Berbamine | |||
| Drug | Aspirin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Down-regulation | Cyclic AMP-dependent transcription factor ATF-1 | Phosphorylation | |
| Result | These data demonstrate that the regulation of cAMP-PKA-CREB/ATF1 signaling represents a noncanonical function of CPS1. Targeting the PKA-CREB/ATF1 axis may be a strategy to improve the therapeutic effects of aspirin on HCC. | |||
