| Name | von Hippel-Lindau disease tumor suppressor | ||
| UniProt ID | VHL_HUMAN | ||
| Gene Name | VHL | ||
| Gene ID | 7428 | ||
| Synonyms |
VHL, HRCA1, RCA1, VHL1, pVHL
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| Sequence |
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa7428 | ||
| TTD ID | T80423 | ||
| Pfam | PF01847; PF17211; PF18770 | ||
| Pair Name | Astaxanthin, Sorafenib | |||
| Phytochemical | Astaxanthin | |||
| Drug | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Up-regulation | von Hippel-Lindau disease tumor suppressor | Phosphorylation | |
| Result | Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment | |||
| No. | Title | Href |
|---|---|---|
| 1 | Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment. Mol Nutr Food Res. 2024 Jan;68(2):e2300569. doi: 10.1002/mnfr.202300569. | Click |
