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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name TIP41-like protein
UniProt ID TIPRL_HUMAN
Gene Name TIPRL
Gene ID 261726
Synonyms
TIPRL, TIP, TIP41, TIPRL1
Sequence
MMIHGFQSSHRDFCFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHG
SGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTL
LGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFF
LLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISSLMHVPPSLFTEPNEISQ
YLPIKEAVCEKLIFPERIDPNPADSQKSTQVE
Pathway Map MAP LINK
KEGG ID hsa261726
Pfam PF04176
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 334
Pair Name Chicoric acid, TNF-related apoptosis inducing ligand
Phytochemical Chicoric acid
Drug TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Regulate Info Down-regulation TIP41-like protein Expression
Result Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy.
03. Reference
No. Title Href
1 Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells. Mol Carcinog. 2016;55(4):387-396. doi:10.1002/mc.22288 Click
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