| Pair Name | Shikonin, Dimethylaminoparthenolide | ||
| Phytochemical Name | Shikonin (PubChem CID: 479503 ) | ||
| Anticancer drug Name | Dimethylaminoparthenolide (PubChem CID: 129395999 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Shikonin, Dimethylaminoparthenolide | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | FN1 | hsa2335 |
| In Vitro Model | Kasumi-2 | Childhood B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0590 |
| KOPN-8 | Childhood B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_1866 | |
| NALM-6 | Adult B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0092 | |
| RCH-ACV | Childhood B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_1851 | |
| Reh | Childhood B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_1650 | |
| Result | This approach demonstrates that a synergistic pair of compounds with malignant cell specificity can effectively target metabolic pathways crucial to leukemia cell proliferation and induce apoptosis. | |||
| No. | Title | Href |
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| 1 | Identification of a synergistic combination of dimethylaminoparthenolide and shikonin alters metabolism and inhibits proliferation of pediatric precursor-B cell acute lymphoblastic leukemia. Mol Carcinog. 2020 Apr;59(4):399-411. doi: 10.1002/mc.23163. | Click |
