| Name | Transcription factor SOX-5 | ||
| UniProt ID | SOX5_HUMAN | ||
| Gene Name | SOX5 | ||
| Gene ID | 6660 | ||
| Synonyms |
SOX5, L-SOX5, L-SOX5B, L-SOX5F, LAMSHF
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| Sequence |
MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPN
KPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQS GESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAM GSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMEL AKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLL PPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGI PQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPAL RINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGK VAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSES RIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNL EKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYF NVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEP HIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa6660 | ||
| TTD ID | T49085 | ||
| Pfam | PF00505; PF09011 | ||
| Pair Name | Ginsenoside Rb1, Apatinib | |||
| Phytochemical | Ginsenoside Rb1 | |||
| Drug | Apatinib | |||
| Disease Info | [ICD-11: 2B6E] | Hypopharyngeal carcinoma | Investigative | |
| Regulate Info | Down-regulation | Transcription factor SOX-5 | Expression | |
| Result | A combination of apatinib and G-Rb1 induced more tumor cell apoptosis and reduced cell proliferation than the individual drug treatment and promote antitumor immunity by enhancing immunomodulatory molecules. Thus, we believe that this study could serve as a valuable platform to assess the synergetic anticancer effects of the herbal as well as synthetic medicines. | |||
