| Name | SHC SH2 domain-binding protein 1 | ||
| UniProt ID | SHCBP_HUMAN | ||
| Gene Name | SHCBP1 | ||
| Gene ID | 79801 | ||
| Synonyms |
SHCBP1, PAL
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| Sequence |
MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE GYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK WNGKGSFGTFLF |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa79801 | ||
| TTD ID | T96542 | ||
| Pfam | PF05048; PF05971; PF10303; PF12708; PF13229; PF14970 | ||
| Pair Name | Theaflavin 3,3'-digallate, Trastuzumab | |||
| Phytochemical | Theaflavin 3,3'-digallate | |||
| Drug | Trastuzumab | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Regulate Info | Down-regulation | SHC SH2 domain-binding protein 1 | Expression | |
| Result | These findings suggest an aberrant mitotic HER2-SHCBP1-PLK1 axis underlies trastuzumab sensitivity and offer a new strategy to combat gastric cancer. | |||
