InterPAD - DETAILS

Ribociclib, 1211441-98-3, LEE011, LEE-011, Ribociclib (LEE011), LEE 011, 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Kisqali, LEE011A, UNII-TK8ERE8P56, TK8ERE8P56, 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, LEE-011A, 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, example 74 (US8962630), example 74 [US8962630], 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo [2,3-d]pyrimidine-6-carboxylic acid dimethylamide, 7-Cyclopentyl-N,N-dimethyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7H-PYRROLO(2,3-D)PYRIMIDINE-6-CARBOXAMIDE, 7-CYCLOPENTYL-N,N-DIMETHYL-2-((5-(1-PIPERAZINYL)-2-PYRIDINYL)AMINO)-, Ribociclib [INN], Ribociclib, LEE011, Ribociclib [USAN:INN], ribociclibum, 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo(2,3-d)pyrimidine-6-carboxamide, 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-; 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; Kisqali; LEE 011; LEE 011A; Ribociclib, RIBOCICLIB [MI], Ribociclib (USAN/INN), RIBOCICLIB [USAN], Ribociclib (LEE011)?, NVP-LEE011, RIBOCICLIB [WHO-DD], SCHEMBL302310, GTPL7383, CHEMBL3545110, EX-A304, L01XE42, CHEBI:230905, RHXHGRAEPCAFML-UHFFFAOYSA-N, BDBM148264, DTXSID201021027, HMS3653N03, HMS3673I19, HMS3748M05, AMY16792, BCP08804, MFCD27976795, NSC778909, NSC794613, NSC800867, s7440, AKOS025404915, AKOS032949987, CCG-269070, CS-1750, DB11730, NSC-778909, NSC-794613, NSC-800867, SB18480, NCGC00386317-10, NCGC00386317-11, AC-30029, AS-10159, DA-35904, HY-15777, LEE-011; LEE 011;LEE011, FT-0700117, NS00072964, SW220101-1, D10883, EN300-7409093, US8962630, 74, A858033, J-690066, Q27088552, 6-(1H-Indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-Imidazo[1,2-a]pyrazin-8-amine, 6ZZ, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

Name	Ribociclib
PubChem CID	44631912
Molecular Weight	434.5g/mol
Synonyms	Ribociclib, 1211441-98-3, LEE011, LEE-011, Ribociclib (LEE011), LEE 011, 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Kisqali, LEE011A, UNII-TK8ERE8P56, TK8ERE8P56, 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, LEE-011A, 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, example 74 (US8962630), example 74 [US8962630], 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo [2,3-d]pyrimidine-6-carboxylic acid dimethylamide, 7-Cyclopentyl-N,N-dimethyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7H-PYRROLO(2,3-D)PYRIMIDINE-6-CARBOXAMIDE, 7-CYCLOPENTYL-N,N-DIMETHYL-2-((5-(1-PIPERAZINYL)-2-PYRIDINYL)AMINO)-, Ribociclib [INN], Ribociclib, LEE011, Ribociclib [USAN:INN], ribociclibum, 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo(2,3-d)pyrimidine-6-carboxamide, 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-; 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; Kisqali; LEE 011; LEE 011A; Ribociclib, RIBOCICLIB [MI], Ribociclib (USAN/INN), RIBOCICLIB [USAN], Ribociclib (LEE011)?, NVP-LEE011, RIBOCICLIB [WHO-DD], SCHEMBL302310, GTPL7383, CHEMBL3545110, EX-A304, L01XE42, CHEBI:230905, RHXHGRAEPCAFML-UHFFFAOYSA-N, BDBM148264, DTXSID201021027, HMS3653N03, HMS3673I19, HMS3748M05, AMY16792, BCP08804, MFCD27976795, NSC778909, NSC794613, NSC800867, s7440, AKOS025404915, AKOS032949987, CCG-269070, CS-1750, DB11730, NSC-778909, NSC-794613, NSC-800867, SB18480, NCGC00386317-10, NCGC00386317-11, AC-30029, AS-10159, DA-35904, HY-15777, LEE-011; LEE 011;LEE011, FT-0700117, NS00072964, SW220101-1, D10883, EN300-7409093, US8962630, 74, A858033, J-690066, Q27088552, 6-(1H-Indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-Imidazo[1,2-a]pyrazin-8-amine, 6ZZ, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide
Drug Type	Small molecule
Formula	C₂₃H₃₀N₈O
SMILES	CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
InChI	1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
InChIKey	RHXHGRAEPCAFML-UHFFFAOYSA-N
CAS Number	1211441-98-3
ChEMBL ID	CHEMBL3545110
TTD ID	D01HVT
Drug Bank ID	DB11730
KEGG ID	D10883
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Escin, Ribociclib
Partner Name	Escin
Result	Neutropenia