| Name | Threonine-protein kinase PLK1 | ||
| UniProt ID | PLK1_HUMAN | ||
| Gene Name | PLK1 | ||
| Gene ID | 5347 | ||
| Synonyms |
PLK1, PLK, STPK13
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| Sequence |
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL KAS |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa5347 | ||
| TTD ID | T40694 | ||
| Pfam | PF00069; PF00659; PF01636; PF03109; PF07714; PF14531 | ||
| Pair Name | Theaflavin 3,3'-digallate, Trastuzumab | |||
| Phytochemical | Theaflavin 3,3'-digallate | |||
| Drug | Trastuzumab | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Regulate Info | Down-regulation | Threonine-protein kinase PLK1 | Expression | |
| Result | These findings suggest an aberrant mitotic HER2-SHCBP1-PLK1 axis underlies trastuzumab sensitivity and offer a new strategy to combat gastric cancer. | |||
