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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name N-glycosylase/DNA lyase
UniProt ID OGG1_HUMAN
Gene Name OGG1
Gene ID 4968
Synonyms
OGG1, HMMH, HOGG1, MUTM, OGH1
Sequence
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLA
DQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHF
QEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHG
FPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKAL
CILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELG
NFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
Pathway Map MAP LINK
KEGG ID hsa4968
TTD ID T92189
Pfam PF00633; PF00730; PF07934; PF21176
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 312
Pair Name Juglone, Temozolomide
Phytochemical Juglone
Drug Temozolomide
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Regulate Info Up-regulation N-glycosylase/DNA lyase Expression
Result Juglone in Combination with Temozolomide Shows a Promising Epigenetic Therapeutic Effect on the Glioblastoma Cell Line
03. Reference
No. Title Href
1 Juglone in Combination with Temozolomide Shows a Promising Epigenetic Therapeutic Effect on the Glioblastoma Cell Line. Int J Mol Sci. 2023 Apr 10;24(8):6998. doi: 10.3390/ijms24086998. Click
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