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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Dehydrodolichyl diphosphate synthase complex subunit NUS1
UniProt ID NGBR_HUMAN
Gene Name NUS1
Gene ID 116150
Synonyms
NUS1, C6orf68, CDG1AA, MGC:7199, MRD55, NgBR, TANGO14
Sequence
MTGLYELVWRVLHALLCLHRTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPP
AVGRNRRHHRHPRGGSCLAAAHHRMRWRADGRSLEKLPVHMGLVITEVEQEPSFSDIASL
VVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEFANSNDKDDQ
VLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDL
VLKFGPVDSTLGFLPWHIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
Pathway Map MAP LINK
KEGG ID hsa116150
Pfam PF01255
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 169
Pair Name Artesunate, Sorafenib
Phytochemical Artesunate
Drug Sorafenib
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Regulate Info Down-regulation Dehydrodolichyl diphosphate synthase complex subunit NUS1 Expression
Result We report that sorafenib treatment in combination with artesunate overcomes HCC resistance to sorafenib alone in a cell culture model.
03. Reference
No. Title Href
1 Artesunate Regulates Neurite Outgrowth Inhibitor Protein B Receptor to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells. Front Pharmacol. 2021 Feb 25;12:615889. doi: 10.3389/fphar.2021.615889. Click
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