| Name | Transcriptional activator Myb | ||
| UniProt ID | MYB_HUMAN | ||
| Gene Name | MYB | ||
| Gene ID | 4602 | ||
| Synonyms |
MYB, Cmyb, c-myb, c-myb_CDS, efg
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| Sequence |
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL LLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLT STPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK YGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNF FCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 2.A.29.23.3; 9.B.278.1.6 | ||
| KEGG ID | hsa4602 | ||
| TTD ID | T99740 | ||
| Pfam | PF00249; PF07988; PF09316; PF09548; PF13921; PF15963; PF16282; PF20222; PF21227 | ||
| Pair Name | Retinoic acid, PI3K inhibitor | |||
| Phytochemical | All-trans-retinoic acid | |||
| Drug | PI3K inhibitor | |||
| Disease Info | [ICD-11: 2D4Y] | Adenoid cystic carcinoma | Investigative | |
| Regulate Info | Down-regulation | Transcriptional activator Myb | Expression | |
| Result | We displayed the morphologically and genetic featured PDXs which recapitulated the heterogeneity of original ACC tumors, indicating that the models could be used as a platform for drug screening for therapy response. The feasibility of combination treatment approaches for dual targets were confirmed, providing new regimens for personalized therapies in ACC. | |||
